What is Felty’s syndrome?

Felty’s syndrome

Rheumatoid arthritis with splenomegaly and neutropenia are called Felty’s syndrome. 

Felty's syndrome = RA + Splenomegaly + neutropenia 

Risk factors of Felty’s syndrome:

• Age of onset 50-70 years
• Female > male
• Caucasians > blacks
• Long-standing RA
• Deforming but inactive disease
• Seropositive for Rheumatoid Factor

Clinical features of Felty’s syndrome:

• Splenomegaly
• Lymphadenopathy
• Weight loss
• Skin pigmentation
• Keratoconjunctivitis sicca
• Vasculitis
• Leg ulcers
• Recurrent infections
• Nodules

[Reproduced from Davidson's principles and practice of medicine 23rd; 1025]

From the Taber's Cyclopedic Medical Dictionary 23rd Edition:

• keratoconjunctivitis: Inflammation of the cornea and the conjunctiva
• Keratoconjunctivitis sicca: Dryness with hyperemia of the conjunctiva in Sjogren’s syndrome due to an autoimmune-mediated decreased lacrimal function.
• Sicca: Came from a Latin word Siccus which means "Dry".