Causes of proximal muscle pain or weakness
A. Inflammatory
- Polymyositis
- Dermatomyositis
- Other autoimmune connective tissue diseases
- Inclusion body myositis
- Sarcoid
- Myasthenia gravis
B. Endocrine
- Hypothyroidism
- Hyperthyroidism
- Cushing's syndrome
- Addison's disease
C. Metabolic
- Myophosphorylase deficiency
- Phosphofructokinase deficiency
- Hypokalaemia
- Carnitine deficiency
- Osteomalacia
- Hypercalcaemia
D. Genetic
- Muscular dystrophy
E. Drugs/toxins
- Alcohol
- Cocaine
- Glucocorticoids
- Statins and fibrates
- Tumour necrosis factor inhibitors
- Zidovudine
F. Infections
- Viral (HIV, cytomegalovirus, rubella, Epstein-Barr, echo)
- Parasitic (schistosomiasis, cysticercosis, toxoplasmosis)
- Bacterial (Clostridium perfringens, staphylococci, tuberculosis, Mycoplasma)
[ Source: Davidson's principles and practice of
medicine 23rd Edition; page 1000]
0 Comments