Autoimmune hepatitis: Type 1 Vs Type 2 Vs Type 3
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The differences between the subtypes of autoimmune hepatitis |
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Clinical features |
Type 1 |
Type 2 |
Type 3 |
|
Diagnostic autoantibodies |
· ASMA (anti-smooth muscle antibodies) · ANA (anti-nuclear antibodies) · Anti-actin (anti-actin antibodies) |
· Anti-LKM (anti Liver kidney microsomal antibodies) · P-450 IID6 autoantibodies · Synthetic core motif peptides 254-271 |
· Soluble liver-kidney antigen · Cytokeratin 8 and 18 |
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Age |
10years to elderly |
Pediatric (2-14 years) Rare in adults |
Adults (30-50 years) |
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Women (%) |
78 |
89 |
90 |
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Concurrent immune disease (%) |
41 |
34 |
58 |
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Gamma globulin elevation |
+++ |
+ |
++ |
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Low IgA |
No |
Occasional |
No |
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HLA association |
B8, DR3, DR4 |
B14, DR3, C4AQO |
Uncertain |
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Steroid response |
++ |
++ |
+++ |
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Progression to cirrhosis (%) |
45 |
82 |
75 |
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